Risk of Skin Cancer Among Patients With Chronic Lymphocytic Leukemia - PubMed
4 hours ago
- #skin cancer
- #chronic lymphocytic leukemia
- #cancer risk
- Patients with chronic lymphocytic leukemia (CLL) have a significantly higher 10-year risk of skin cancer (13.5%) compared to matched controls (6.9%), with an absolute risk difference of 6.6 percentage points.
- The most common skin cancer subtypes in CLL patients are basal cell carcinoma (8.6% vs. 5.4% in controls) and squamous cell carcinoma (4.7% vs. 1.4% in controls), both showing substantially increased risks.
- CLL patients also face elevated risks of skin cancer metastasis (0.7% vs. 0.1%) and skin cancer-specific death (0.3% vs. 0.1%), although absolute risks remain low due to high overall mortality in this group.
- The study is a nationwide Danish cohort analysis from 1990-2020, involving 8,352 CLL patients matched 1:5 with controls, adjusting for demographics, comorbidities, and using competing risk models.
- All-cause mortality is notably higher in CLL patients (56.3%) than controls (39.3%), underscoring the broader health impacts of CLL beyond skin cancer risks.