Clinical practice guideline for long COVID prevention and treatment - PubMed
2 hours ago
- #clinical guideline
- #long COVID
- #evidence-based medicine
- Guideline aims to provide evidence-based recommendations for long COVID prevention and treatment.
- Target population: adults with long COVID.
- Primary users: clinical physicians, pharmacists, nurses, and general practitioners worldwide.
- Multidisciplinary working group included 60 members from 10 countries and 10 areas of expertise.
- Eight PICO questions were addressed focusing on prevention and treatment.
- Three rounds of Delphi survey conducted among 24 international experts to reach consensus.
- GRADE approach used to rate evidence certainty and determine recommendation strength.
- 10 specific recommendations provided, supported by systematic reviews.
- Key recommendations include vaccination/antiviral use in acute phase, against nirmatrelvir-ritonavir and glucocorticoids, and for multi-species probiotics, cognitive behavioral therapy, and personalized rehabilitation.
- All recommendations supported by very low to moderate certainty evidence; further high-quality studies needed.