Clinical and molecular characteristics, antibiotic susceptibility, risk factors and predictors of mortality in carbapenem-resistant klebsiella pneumoniae bloodstream infections in Southern Sichuan, Ch
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- #molecular epidemiology
- #bloodstream infections
- #CRKP
- Study focused on carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections (BSI) in Southern Sichuan, China.
- 430 cases analyzed, with 66 CRKP-BSI cases identified; highest isolation rate in ICU (28.8%).
- CRKP showed high resistance to carbapenems (>92.2%) and a 28-day mortality rate of 43.9%.
- Independent risk factors for CRKP-BSI included pulmonary infection, ICU stay >3 days, invasive catheters, and use of ≥3 antibiotics.
- Mechanical ventilation and corticosteroid use >7 days were predictors of mortality.
- Molecular epidemiology revealed ST11 as the dominant clone (43.33%) with three new sequence types identified.
- Common carbapenemase genes: blaKPC-2 (60.0%) and blaNDM-5 (20.0%); common virulence gene: ybtA (76.7%).
- High biofilm formation positivity (83.3%) but low hypermucoviscous phenotype (6.67%).
- Findings highlight need for enhanced surveillance and targeted interventions to manage CRKP-BSI.