Identification of common genetic and molecular signatures in migraine and comorbid conditions - PubMed
6 hours ago
- #neuroinflammation
- #comorbidity
- #migraine
- Migraine is a common neurological disorder associated with significant disability and social burden.
- Migraine often coexists with various systemic comorbidities, including epilepsy, psychiatric disorders, sleep disturbances, cardio-cerebrovascular diseases, multiple sclerosis, asthma, chronic pain syndromes, gastrointestinal disorders, and metabolic-endocrine abnormalities.
- Comorbid conditions are linked to increased migraine severity, higher chronification rates, poorer treatment responses, and greater healthcare use.
- Shared biological pathways between migraine and comorbidities include dysregulation of neurovascular signaling, neuroinflammation, central sensitization, autonomic nervous system alterations, and immune/metabolic disturbances.
- Comorbidities can affect treatment efficacy, tolerance, and safety, highlighting limitations of symptom-focused approaches.
- The review synthesizes evidence on epidemiological associations, shared mechanisms, and clinical implications to inform comprehensive, personalized, mechanism-based management strategies.
- Future research should focus on identifying biomarkers and refining patient stratification for precision medicine in migraine and related conditions.