Circ-Eif3c Carried by M2 Macrophage-Derived Exosomes Mitigates Asthma Progression via miR-15a-5p/GSS/SOCS6 Axis Inhibition - PubMed
3 days ago
- #exosomes
- #asthma
- #macrophage
- M2 macrophage-derived exosomes (M2-Exos) mitigate asthma progression by carrying circ-Eif3c.
- Circ-Eif3c targets the miR-15a-5p/GSS/SOCS6 axis to suppress inflammation and lung injury in asthma models.
- Overexpression of circ-Eif3c enhances the therapeutic effects of M2-Exos on alveolar epithelial cell (AEC) damage.
- Bioinformatics and luciferase assays confirm interactions between circ-Eif3c, miR-15a-5p, GSS, and SOCS6.
- Circ-Eif3c-enriched M2-Exos help restore AEC function and attenuate airway remodeling in asthma.