Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder - PubMed
3 hours ago
- #Parkinson's disease
- #REM sleep behavior disorder
- #metabolomics
- RBD-PD patients show distinct metabolic reprogramming: shift from TCA cycle to glycolysis, dysregulated urea cycle, lipid remodeling, and increased inflammatory/immune responses.
- Disturbances in RBD-PD include accumulation of gut microbiota-derived toxic aromatic amino acid catabolites, also observed in idiopathic RBD patients.
- Gut microbial dysbiosis in RBD-PD and iRBD drives functional shifts away from fiber fermentation towards enhanced protein/amino acid degradation, linked to oxidative stress and neuroinflammation.
- The study highlights gut microbiota-driven dysfunction as a key contributor to both iRBD and RBD-PD subtypes, clarifying molecular heterogeneity in Parkinson's disease.