Sex Differences in Outcomes After Breakthrough Ischemic Stroke on Oral Anticoagulants for Atrial Fibrillation: An ASPERA-R Inverse Probability Weighted Analysis - PubMed
4 hours ago
- #Breakthrough Stroke
- #Oral Anticoagulation
- #Sex Differences
- The study explores sex-specific outcomes in patients experiencing a breakthrough ischemic stroke while on oral anticoagulation for atrial fibrillation.
- Women were older, had higher baseline stroke severity, and worse pre-stroke functional status compared to men.
- After statistical adjustment, women had a lower likelihood of returning to baseline neurologic function at 90 days.
- Women also had worse overall functional outcomes and a higher rate of recurrent ischemic stroke or transient ischemic attack.
- A trend toward more moderate-to-severe bleeding events was observed in women, though not statistically significant.
- Subgroup analyses identified interactions between sex and factors like OAC type, competing causes, endovascular treatment, and OAC restart.
- The findings emphasize the importance of considering sex differences in the management of such patients.