Telomere length and clonal hematopoiesis interact to influence outcomes in hematopoietic stem cell transplantation - PubMed
4 hours ago
- #hematopoietic stem cell transplantation
- #telomere length
- #clonal hematopoiesis
- Clonal hematopoiesis (CH) is linked to worse survival in autologous stem cell transplant (ASCT) recipients.
- Leukocyte telomere length (LTL) interacts with CH, but its impact on stem cell transplantation (SCT) was unclear.
- Study measured LTL in 452 myeloma patients undergoing ASCT, with CH driver gene mutation data available.
- Longer LTL improved progression-free survival (PFS) in patients without CH, but not in those with CH.
- In CH patients, longer LTL correlated with higher red cell distribution width (RDW) before and after ASCT.
- Findings reveal new interactions between LTL, CH, and ASCT outcomes.