Phase separation of DDHD2 remodels lipid metabolism to dictate treatment sensitivity in luminal breast cancer - PubMed
12 hours ago
- #DDHD2
- #lipid metabolism
- #ferroptosis
- Phase separation of DDHD2 plays a key role in lipid metabolism remodeling in luminal breast cancer.
- Aberrant lipid metabolism negatively affects the prognosis of luminal breast cancer patients.
- DDHD2 forms biomolecular condensates via phase separation upon AKT1-mediated phosphorylation, enhancing its lipase activity.
- DDHD2 condensates reduce proferroptotic lipids, decreasing ferroptosis susceptibility in luminal breast cancer.
- The DDHD2 inhibitor KLH45 enhances ferroptosis sensitivity and restricts cancer progression.
- Combining KLH45 with ferroptosis inducers improves the efficacy of endocrine therapy in luminal breast cancer.