Glomerular endothelial rarefaction associated with hypoxic neutrophils marks renal pathology activity in lupus nephritis - PubMed
3 days ago
- #neutrophil NETosis
- #glomerular hypoxia
- #lupus nephritis
- Glomerular endothelial rarefaction in lupus nephritis (LN) is linked to hypoxia and hypoxic neutrophils.
- LN glomeruli show increased HIF1α-expressing macrophages and neutrophils, along with evidence of NETosis.
- Spatial transcriptomics analysis reveals a correlation between glomerular hypoxia and neutrophil extracellular trap (NET) formation.
- Renal pathology Activity Index correlates with hypoxic neutrophil count and glomerular endothelial damage.
- Elevated urinary neutrophil cargo proteins (MPO and proteinase 3) indicate potential for liquid biopsy monitoring.