Genomic evidence of convergence of multidrug resistance and enhanced virulence in carbapenem- and colistin-resistant Klebsiella pneumoniae from Turkey - PubMed
4 hours ago
- #Klebsiella pneumoniae
- #Genomic Surveillance
- #Antimicrobial Resistance
- Study analyzed genomic data of carbapenem- and/or colistin-resistant Klebsiella pneumoniae isolates from hospitalized patients in Turkey.
- Predominant clonal group was CG14 (ST2096, ST14, ST8972), with ST2096 isolates showing international spread.
- Carbapenem resistance primarily driven by blaOXA-48-like genes, and colistin resistance by chromosomal mutations in mgrB and pmrB, with no plasmid-mediated mcr genes.
- 77.3% of isolates exhibited convergence of antimicrobial resistance and high virulence potential genotypes.
- Highlights urgent need for robust One Health genomic surveillance and improved antimicrobial stewardship and infection control globally.