Next-generation programmable cell therapies for precision medicine - PubMed
12 hours ago
- #synthetic biology
- #cell therapy
- #precision medicine
- Engineered cell therapies are advancing precision medicine by enabling real-time, context-responsive interventions.
- Next-generation platforms are expanding beyond CAR-T cells to include diverse immune and stem cells for broader disease applications.
- Synthetic gene circuits are used to induce targeted cytotoxicity, modulate effector protein secretion, or coordinate both functions in response to signals.
- Ex vivo engineering of autologous cells is common, but scalability and cost challenges are driving research into allogeneic products and in vivo reprogramming.
- Innovations in targeted delivery methods, such as viral vectors, mRNA-loaded nanoparticles, and virus-like particles, are enhancing in vivo cell programming.
- The review highlights modular control systems, delivery innovations, and translational challenges in the field of programmable cell therapies.