Interstitial lung involvement in rheumatoid arthritis patients treated with abatacept: a prospective observational study - PubMed
19 hours ago
- #interstitial lung disease
- #abatacept
- #rheumatoid arthritis
- Prospective multicenter observational study of 325 RA patients on abatacept, followed for 24 months.
- At enrollment, ILD prevalence was 20.6%; in ILD patients, >85% improved or remained stable, while 14.9% worsened, mainly with usual interstitial pneumonia.
- No patients discontinued abatacept due to lung function decline; no difference in two-year retention rates between those with and without ILD.
- Incidence rate of new-onset ILD was 0.39 per 100 patients per year, with regular assessments using VECTOR software for velcro crackles detection.
- Study suggests abatacept may be effective for RA-ILD, as ILD presence did not impact drug retention.