CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis - PubMed
3 hours ago
- #ER function
- #lipid homeostasis
- #phospholipid scrambling
- CLCC1 regulates cellular lipid partition and systemic lipid homeostasis by participating in trans-bilayer equilibration of phospholipids.
- CLCC1 partners with TMEM41B to recognize imbalanced bilayers and promote lipid scrambling, supporting lipoprotein biogenesis and bulk lipid transport.
- Loss of CLCC1 or TMEM41B leads to giant lumenal lipid droplets and accelerates metabolic-dysfunction-associated liver steatohepatitis.
- Phospholipid scrambling at the ER is essential for establishing a dynamic equilibrium in lipid biogenesis and distribution.