The Ki-67 proliferation index and recurrence risk of intracranial meningioma: a multicenter, retrospective cohort study of 5,050 patients - PubMed
5 hours ago
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- #recurrence
- #meningioma
- Ki-67 proliferation index (Ki-67 PI) prognostic value varies by WHO grade and extent of resection (Simpson grade) in intracranial meningiomas.
- Ki-67 PI more accurately predicts 10-year recurrence risk in WHO-2 meningiomas than in WHO-1 meningiomas for patients with the same Simpson grade (1-3).
- Within WHO-1 and WHO-2 meningiomas, Ki-67 PI predictive accuracy increases with higher Simpson grade (1-3), but shows no predictive value for Simpson grade 4 resections.
- Combining Ki-67 PI with WHO grade and resection extent may help refine individual surveillance strategies for meningioma patients with gross total resection in the first 10 years post-surgery.
- Study limitations include a 10-year timeframe; findings may not extrapolate beyond this, especially for WHO-1 tumors with low Ki-67 PI and Simpson grade 1 resection.