G6PD facilitates axon regeneration via clathrin-mediated endocytosis - PubMed
5 days ago
- #axon-regeneration
- #G6PD
- #endocytosis
- G6PD, a key enzyme in the pentose phosphate pathway, is upregulated after sciatic nerve injury.
- G6PD plays a crucial role in axon regeneration, with its silencing impairing and overexpression enhancing regrowth.
- G6PD interacts with clathrin heavy chain (CLTC) to facilitate neuronal endocytosis, promoting axon regeneration.
- The study reveals a non-metabolic role of G6PD in neural repair, linking metabolic reprogramming to membrane trafficking.