Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics - PubMed
3 days ago
- #immunotherapy
- #STAT signaling
- #Trikines
- Engineered 'Trikines' create three-chain cytokine receptor complexes at the cell surface.
- Trikines induce unique STAT transcriptional signaling programs distinct from natural cytokines.
- IL-2-based Trikine promotes T cell stemness and enhances tumor control without toxicity.
- IL-10-based Trikine boosts immune infiltration in poorly immunogenic tumors like small cell lung and pancreatic cancers.
- Trikines offer a cell engineering-free approach to customize STAT signatures for immunotherapy.