Hydrogen as a Potential Modulator: Implications for Mast Cell-Sleep-Wake Rhythm-Melatonin Interactions in Sleep Disorders - PubMed
4 hours ago
- #Mast Cells
- #Sleep Disorders
- #Hydrogen Therapy
- Sleep disorders like chronic insomnia, OSA, and sleep fragmentation are linked to dysregulated interactions among immune-inflammatory pathways, circadian timing, and melatonin systems, with mast cells playing a key role.
- Hydrogen's potential sleep-improving effects are hypothesized to be indirect, mediated by antioxidant, anti-inflammatory, and mitochondrial protective properties, rather than directly targeting the mast cell-sleep-wake rhythm-melatonin triad or circadian clock TTFL.
- Current evidence on hydrogen's sleep-related effects is inconsistent, context-dependent, and limited by methodological shortcomings; direct experimental evidence for its specific action on the mast cell-sleep-wake rhythm-melatonin interactions is lacking.
- Hydrogen may alleviate sleep disturbances linked to oxidative stress and inflammation but is unlikely to target distinct pathophysiology of disorders like RLS or OSA, and causal claims about direct regulation are speculative.
- This review provides a novel theoretical framework integrating hydrogen with the mast cell-sleep-wake rhythm-melatonin axis, highlighting shared pathological targets and testable hypotheses, but future studies are needed to clarify efficacy and indirect regulatory pathways.