Optimisation and application of a T-cell antigen-specific activation assay as diagnostic and treatment-monitoring tool for tuberculosis - PubMed
a day ago
- #biomarker
- #tuberculosis
- #diagnostic tool
- TB-TASA (T-cell antigen-specific activation assay) is evaluated as a diagnostic and treatment-monitoring tool for tuberculosis (TB).
- Higher TB-TASA scores were observed in TB patients compared to interferon-γ release assay positive (IGRA+) controls.
- A TB-TASA positivity threshold of 10% HLA-DR+ mycobacteria-specific T-cells was established with sensitivity and specificity >90% and >70%, respectively.
- In a clinical trial, higher TB-TASA scores at treatment completion were linked to relapse or treatment failure (ROC AUC of 0.89).
- TB-TASA was reliably measured in capillary blood via fingerprick, achieving an ROC AUC of 0.96 with 95% sensitivity and 69% specificity.
- The study supports TB-TASA as a potential tool for diagnosing TB and monitoring treatment responses.