Extracellular Vesicles and Endocrine Disruption: How Environmental Pollutants Modulate the Loading and Release of Extracellular Vesicles for Cancer Promotion and Progression - PubMed
3 hours ago
- #endocrine disruptors
- #cancer
- #extracellular vesicles
- Extracellular vesicles (EVs) mediate intercellular communication by transferring bioactive cargo like proteins, lipids, and nucleic acids.
- Endocrine-disrupting chemicals (EDCs) can alter hormonal homeostasis and contribute to cancer initiation, development, and progression.
- Pollutants such as arsenic, bisphenol A, phthalates, and cigarette smoke modify EV secretion and content, influencing oncogenic mechanisms.
- Altered EVs may trigger proliferation, angiogenesis, migration, immunosuppression, and metastasis in recipient cells.
- EVs serve as a promising platform for studying the exposome's role in tumor development and environmental exposure monitoring.