Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction - PubMed
a day ago
- #Sarcopenia
- #Accelerated Aging
- #Cerebral Palsy
- Cerebral palsy (CP) is the leading cause of childhood-onset physical disability, characterized by motor impairments, muscle weakness, and fatigue.
- Individuals with CP often experience early declines in physical performance and functional ability, resembling age-related muscle loss (sarcopenia).
- The paper hypothesizes that CP skeletal muscles undergo accelerated aging, sharing mechanisms with sarcopenia, such as neuromuscular changes and mitochondrial dysfunction.
- Proposed studies aim to test this hypothesis by examining aging markers like DNA methylation and cellular senescence in CP.
- If confirmed, the hypothesis could lead to repurposing geriatric therapies for CP patients.