Vitamin B3 rescues mitochondrial homeostasis in dexamethasone-induced skeletal muscle atrophy by reducing oxidative stress - PubMed
3 hours ago
- #Mitochondrial Homeostasis
- #Vitamin B3
- #Skeletal Muscle Atrophy
- Dexamethasone (dex) induces skeletal muscle atrophy by promoting oxidative stress, mitochondrial dysfunction, and impaired myogenesis.
- Vitamin B3 (vit B3) reduces dex-induced oxidative stress, restores mitochondrial membrane potential, and prevents DNA damage in C2C12 myoblasts.
- Vit B3 enhances mitochondrial fusion (increased Mfn1, Mfn2, Opa1) and reduces fission (decreased Fis1, Drp1), improving mitochondrial homeostasis.
- Vit B3 supplementation rescues NADH levels, supporting better energy production via the electron transport system.
- Vit B3 modulates the IKK/FoxO3a axis to suppress inflammation and prevent muscle proteolysis, countering atrophy markers.
- Vit B3 improves myogenic differentiation, as shown by increased expression of MyoD and MyHC1, enhancing muscle cell viability and health.
- The study highlights vit B3 as a potential therapeutic and nutritional supplement for maintaining skeletal muscle health under myopathic conditions.