Valproate Use by Fathers and Risk of Neurodevelopmental Disorders in Children - PubMed
4 hours ago
- #valproate
- #paternal exposure
- #neurodevelopmental disorders
- Study examines paternal valproate use before conception and risk of neurodevelopmental disorders (NDDs) in offspring.
- Data from Norway and Taiwan analyzed, with 319 and 564 exposed offspring respectively.
- Crude hazard ratios showed increased NDD risk (1.67 in Norway, 1.35 in Taiwan).
- After adjustment, no significant increased risk found in indication-restricted or active-comparator analyses.
- Conclusion: Paternal valproate use not associated with increased NDD risk after confounding adjustment.