Arsenic-Cadmium Co-exposure Rewires Lipid-Iron Homeostasis to Drive Ferroptosis in Human Proximal Tubular Cells - PubMed
3 hours ago
- #Nephrotoxicity
- #Lipid Peroxidation
- #Ferroptosis
- Arsenic (As) and cadmium (Cd) co-exposure in human HK-2 cells leads to ferroptosis by disrupting lipid-iron homeostasis.
- Co-exposure caused significant transcriptional shifts in iron handling, glutathione-cysteine metabolism, and lipid remodeling pathways.
- Protein analysis showed decreased GPX4 and SLC7A11, while ACSL4, PTGS2, and TFR1 increased, indicating ferroptosis activation.
- BODIPY C11 imaging confirmed the highest lipid-peroxide burden in the As + Cd group.
- The study suggests ferroptosis inhibition and iron handling as potential therapeutic targets for mixed-metal nephrotoxicity.