stVCR: spatiotemporal dynamics of single cells - PubMed
3 hours ago
- #deep learning
- #single-cell analysis
- #spatiotemporal dynamics
- stVCR is a generative deep-learning framework for reconstructing spatiotemporal dynamics of single cells.
- It addresses challenges in time-series spatial transcriptomics by integrating dynamical optimal transport, density matching, and biologically informed priors.
- The model enables interpretable analysis of phenotype transitions, spatial migration, and proliferation.
- Demonstrated effectiveness with simulated and real datasets, including axolotl brain regeneration and 3D Drosophila embryo development.
- Authors declare no competing interests.