Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment-Resistant Subclones at the Time of Diagnosis - PubMed
2 days ago
- #Single-cell RNA sequencing
- #Mantle Cell Lymphoma
- #Clonal Evolution
- Single-cell RNA sequencing reveals treatment-resistant subclones in Mantle Cell Lymphoma (MCL) at diagnosis.
- Copy number variants (CNVs) show minor subclones at diagnosis evolve into dominant relapse clones.
- Gene set enrichment analysis highlights heterogeneity in resistance-associated transcriptional programs among patients.
- Convergent dysregulation of cell-cycle control pathways is a shared feature across resistant subclones.
- A case of SOX11-negative indolent MCL (iMCL) shows spatially restricted clonal evolution with aggressive features in intestinal cells.
- Early relapse in MCL originates from pre-existing therapy-resistant subclones selected under treatment pressure.
- Disease progression in iMCL may involve distinct anatomical compartments acquiring aggressive molecular traits.