A Narrative Review of Necroptosis in Neuromuscular Junction Disorders: Pathogenesis and Therapeutic Strategies - PubMed
6 days ago
- #Necroptosis
- #Therapeutic Strategies
- #Neuromuscular Junction
- Necroptosis is a regulated and inflammatory form of cell death linked to neuromuscular junction (NMJ) dysfunction.
- Key mediators of necroptosis include RIPK1, RIPK3, and MLKL, which contribute to NMJ degradation.
- Necroptosis affects various NMJ components, including motor neurons, Schwann cells, and skeletal muscle.
- Conditions like spinal muscular atrophy, amyotrophic lateral sclerosis, and Duchenne muscular dystrophy show necroptosis-related structural and functional deficits.
- Preclinical studies suggest therapeutic potential in targeting necroptosis with RIPK1, RIPK3, and MLKL inhibitors.
- Current evidence is mainly from animal models, with clinical applicability still uncertain and requiring further trials.
- Understanding necroptosis as a shared mechanism may help develop strategies to preserve neuromuscular function.