ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1-STAT3 Pathway - PubMed
4 days ago
- #JAK-STAT Pathway
- #Neuroinflammation
- #Traditional Chinese Medicine
- SQDHD shows neuroprotective effects in NPSLE by inhibiting JAK1-STAT3 pathway.
- Study uses PIL mice to demonstrate SQDHD's efficacy in reducing neuroinflammation and improving behavioral symptoms.
- Five active compounds in SQDHD (Alisol B acetate, Hederagenin, Ellagic acid, Wogonin, Quercetin) bind strongly to JAK1.
- SQDHD reduces BBB leakage, leukocyte recruitment, and cytokine overexpression in the brain.
- Findings suggest SQDHD as a potential therapeutic strategy for NPSLE.