Sidaxue ameliorates rheumatoid arthritis by inhibiting synovial neutrophil migration: Insights from an integrated multi-omics analysis - PubMed
7 hours ago
- #Neutrophil migration
- #Traditional medicine
- #Rheumatoid arthritis
- Sidaxue (SX), a traditional Miao herbal formula, shows potential in ameliorating rheumatoid arthritis (RA).
- The study focuses on SX's mechanism of inhibiting neutrophil migration and activation in RA.
- Multi-omics analysis identified the RAC1/PAK1 pathway as central to neutrophil migration in RA.
- SX contains 38 major compounds with high binding affinity to RAC1 and PAK1.
- SX-containing serum inhibits PMA-induced neutrophil migration, NETs formation, and pro-inflammatory cytokine release.
- In vivo, SX alleviates joint swelling and synovitis in CIA rats by downregulating the RAC1/PAK1/LIMK1/Cofilin1 pathway.
- The study supports SX's development as a natural therapeutic for RA.