Association of depression severity and transition patterns of cardiometabolic multimorbidity - PubMed
3 hours ago
- #depression
- #public health
- #cardiometabolic multimorbidity
- Study assesses depression severity's link to cardiometabolic multimorbidity (CMM) in middle-aged and older Chinese adults.
- Data from 12,059 CHARLS participants analyzed; depression categorized as none, mild-moderate, or severe using CES-D-10 scores.
- CMM defined as coexistence of two or more conditions: type 2 diabetes, heart disease, or stroke.
- Mild-moderate and severe depression associated with increased risk of first cardiometabolic disease (FCMD).
- Severe depression linked to higher risk of CMM and transition from FCMD to CMM.
- Multi-state models show depression increases risk of transitioning from health to FCMD and death.
- Results robust in subgroup and sensitivity analyses.
- Targeted depression interventions may help delay CMM development.