Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity - PubMed
3 hours ago
- #autoimmunity
- #cancer-immunity
- #NMDAR
- Ectopic NMDAR expression in triple-negative breast cancer (TNBC) triggers B cell recruitment and affinity maturation.
- Affinity-matured anti-NMDAR antibodies originate from pre-existing germline-configuration antibodies.
- Matured antibodies target specific NMDAR epitopes, causing functional effects ranging from inhibition to potentiation.
- Passive transfer of an NMDAR-potentiating antibody in mice recapitulates symptoms of anti-NMDAR encephalitis (ANRE).
- Intratumoral NMDAR expression correlates with anti-NMDAR antibody titers in TNBC patients.
- Findings reveal a trade-off between cancer immunity (via immune surveillance) and neurotoxicity (via autoimmunity).