Ferroptosis in MASLD: From molecular mechanisms to therapeutic opportunities - PubMed
4 hours ago
- #Ferroptosis
- #MASLD
- #Therapeutic Targeting
- Ferroptosis, an iron-dependent cell death via lipid peroxidation, is a key pathogenic mechanism in Metabolic dysfunction-associated steatotic liver disease (MASLD).
- The liver's role in iron and lipid metabolism makes hepatocytes highly vulnerable to ferroptotic injury, driving oxidative stress, inflammation, and fibrosis in MASLD progression.
- Ferroptosis also connects to systemic metabolic dysfunction and extrahepatic organ involvement in MASLD, highlighting its broader impact beyond the liver.
- The review explores molecular pathways linking ferroptosis to MASLD, including evidence from preclinical and clinical studies.
- Potential therapeutic strategies targeting ferroptosis include iron chelation, antioxidants, and lipid peroxidation inhibitors, alongside emerging biomarkers for MASLD.