Association between chronic inflammation status and serum testosterone and free testosterone in adult males - PubMed
3 days ago
- #testosterone
- #chronic inflammation
- #NHANES
- Chronic inflammation may contribute to biochemical hypogonadism in adult males.
- The study used data from NHANES 2011-2016 and 2021-2023, analyzing 7,576 men for serum testosterone and 3,590 for free testosterone (FT).
- Higher systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) were significantly associated with lower serum testosterone and FT levels.
- Nonlinear inverse associations were observed between SIRI/AISI and serum testosterone, while AISI showed a nonlinear association with FT and SIRI showed a linear inverse association.
- The inverse associations with serum testosterone were consistent across all ages, but associations with FT were age-dependent, evident only in men aged 20-39 and ≥60 years.
- SIRI and AISI are independently associated with lower serum testosterone, while associations with FT vary by age.