Hypertension-Associated Acetate Deficiency Enhances Platelet Activation and Thrombosis Via Olfr78 - PubMed
4 hours ago
- #hypertension
- #thrombosis
- #platelet activation
- Hypertension-associated acetate deficiency enhances platelet activation and thrombosis via Olfr78.
- Gut dysbiosis in hypertension leads to endothelial dysfunction and systemic inflammation, contributing to cardiovascular complications.
- Fecal microbiota transplantation from hypertensive patients increased thrombosis compared to healthy subjects.
- Acetate levels were lower in hypertensive patients and negatively correlated with platelet activation markers.
- Acetate showed superior antiplatelet effects against ADP-induced aggregation compared to collagen or thrombin.
- Mechanistic studies revealed acetate binds to Olfr78 in platelets, elevating cAMP and inhibiting platelet activation pathways.
- A high-fiber diet upregulated acetate/Olfr78 signaling, reducing thrombosis and myocardial injury in mice.
- Acetate deficiency contributes to platelet hyperreactivity in hypertension, suggesting dietary interventions as potential treatments.