Treatment of bipolar depression: results from a comprehensive network meta-analysis and updated systematic review - PubMed
5 hours ago
- #Network Meta-analysis
- #Bipolar Depression
- #Systematic Review
- Depressive episodes in bipolar disorder (BD) present a treatment challenge, necessitating novel options.
- A network meta-analysis (NMA) synthesized 145 studies, quantitatively analyzing 101 for acute bipolar depression treatment.
- Effective treatments over placebo include olanzapine plus fluoxetine, quetiapine, olanzapine, lurasidone, lumateperone, cariprazine, and lamotrigine.
- A complementary systematic review identified 24 clinical trials, with seven suitable for meta-analysis.
- Findings aim to inform evidence-based care and international treatment guidelines for bipolar depression.