Adhesion-Related Macrophages Regulate Metabolic Homeostasis Through CAV-1 Dependency - PubMed
a day ago
- #obesity
- #macrophages
- #insulin resistance
- Adhesion-related macrophages (ARMs) are a newly identified subpopulation of adipose tissue macrophages (ATMs) that adhere to adipocytes.
- ARMs expand predominantly during obesity and acquire adipocyte mRNA, enhancing their lipid processing capacity.
- Caveolin-1 (CAV-1) is a key functional marker for ARMs; its genetic ablation reduces ARM abundance and disrupts metabolic homeostasis.
- Loss of CAV-1 in macrophages leads to adipocyte hypertrophy, adipose tissue expansion, and impaired glucose homeostasis.
- Reintroducing ARMs from lean mice into obese mice mitigates insulin resistance, suggesting therapeutic potential.
- The study highlights ARMs as a potential target for treating obesity-induced insulin resistance.