MVP Inhibits Influenza A Virus-Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity - PubMed
2 hours ago
- #MVP
- #Influenza A Virus
- #ferroptosis
- MVP (Major Vault Protein) inhibits Influenza A Virus (IAV)-induced ferroptosis by targeting IRF1 and increasing FSP1 activity.
- MVP expression positively correlates with IRF1 and FSP1, but not GPX4, in IAV-infected patients.
- MVP suppresses IRF1 polyubiquitination and nuclear localization by sequestering it from TRAF6, enhancing FSP1 expression.
- MVP also promotes FSP1's ubiquitination and myristoylation, enabling its recruitment to the plasma membrane to function as an oxidoreductase.
- The study identifies a novel ferroptosis suppression pathway during IAV infection.