Sequential Small-Molecule Therapy for Lymphocytic Cicatricial Alopecia: A Multicenter Prospective Cohort Pilot Study - PubMed
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- #Small-Molecule Therapy
- #Dermatology
- #Lymphocytic Cicatricial Alopecia
- Study evaluates sequential small-molecule therapy for Lymphocytic Cicatricial Alopecia (LCA).
- Three-stage regimen includes Tofacitinib + Crisaborole (Stage I), Apremilast + Crisaborole (Stage II), and Crisaborole alone (Stage III).
- Significant reduction in Lichen Planopilaris Activity Index (LPPAI) observed, with 85.5% improvement rate.
- 93.5% of patients showed marked improvement with minimal adverse events.
- Limitations include small sample size, no control group, and short follow-up.