Frailty: An overview - PubMed

a day ago

Frailty is a global health concern linked to aging and multimorbidity.
It is a geriatric syndrome with reduced physiological reserve and increased vulnerability to stressors.
Prevalence ranges from 4-16% in community-dwelling older adults to over 40% in clinical subgroups.
Higher frailty rates are observed in women and the oldest-old.
Etiology includes sarcopenia, chronic inflammation, endocrine dysregulation, and nutritional deficits.
Pathophysiological mechanisms involve inflammaging, mitochondrial dysfunction, and metabolic alterations.
Diagnosis uses tools like Fried Frailty Phenotype, Frailty Index, and Clinical Frailty Scale.
Management requires a multidisciplinary approach: exercise, nutrition, medication review, and psychosocial support.
Early identification and tailored interventions are crucial to mitigate frailty's impact.
There is a need for integrated care models, especially in low- and middle-income countries.

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