Association of Cardiovascular-Kidney-Syndrome and Brain Macrostructure and Microstructure Injury: A Prospective Cohort Study - PubMed
4 hours ago
- #brain health
- #CKM syndrome
- #white matter
- Study examines associations between cardiovascular-kidney-metabolic (CKM) syndrome stages and brain macrostructure/microstructure.
- Prospective cohort study with 3067 adults aged 50-75 years, using CKM staging (Stages 0-4).
- Advanced CKM stages (3-4) linked to reduced brain volumes and increased white matter hyperintensity volume (WMHV).
- Higher baseline CKM stages (2-3) associated with accelerated brain volume declines and faster WMHV progression over 4.7 years.
- DTI shows progressive white matter microstructural deterioration, from focal alterations in early stages to widespread integrity loss in Stage 4.
- Findings highlight the importance of early CKM syndrome identification to mitigate brain health decline.