Thiamine pyrophosphate suppresses platelet activation by modulating PI3K-Akt and MAPK pathways: An integrated network pharmacology and experimental study - PubMed
4 hours ago
- #Thiamine pyrophosphate
- #Cardiovascular health
- #Platelet activation
- Thiamine pyrophosphate (TPP) suppresses platelet activation, potentially aiding in thrombosis prevention.
- TPP modulates PI3K-Akt and MAPK pathways, key signaling routes in platelet function.
- In vitro studies show TPP inhibits platelet aggregation, adhesion, and spreading without affecting cell viability.
- Network pharmacology identified 177 potential targets linking TPP to thrombosis, highlighting PI3K-Akt and MAPK pathways.
- In vivo, TPP reduced arterial thrombosis in mice without impairing normal hemostasis.
- Findings suggest TPP could be a promising antiplatelet drug, bridging nutrition and cardiovascular health.