Spatial multi-omics of multiple myeloma uncovers niche-dependent pro-myeloma and immunosuppressive signaling in the bone marrow and extramedullary lesions - PubMed
4 hours ago
- #bone marrow niche
- #spatial transcriptomics
- #multiple myeloma
- Researchers developed a multimodal spatial multi-omics framework integrating Visium HD, Xenium, and scRNA-seq to profile multiple myeloma (MM) interactions with the bone marrow microenvironment.
- The study identified plasma cell-dense niches enriched with non-canonical Wnt signaling, linked to drug resistance, poor survival, and extramedullary lesions.
- Immune cells within these niches showed suppressed states, including increased inhibitory receptors like LAG3, and a 15-gene signature from niche-driven states predicted progression-free survival.