A single extinction-based treatment with N-Acetylcysteine produces long-term reduction in cocaine relapse - PubMed
4 hours ago
- #relapse prevention
- #N-Acetylcysteine
- #cocaine addiction
- N-Acetylcysteine (NAC) reduces cocaine relapse in a single extinction-based treatment.
- NAC normalizes glutamate function, potentially via mGlu2/3 receptor activation.
- A single dose of NAC (100 mg/kg) before extinction training significantly reduces cocaine-seeking behavior on the first day.
- NAC's effects last at least 28 days, reducing cue-induced and context-induced reinstatement.
- The mGlu2/3 antagonist LY341495 blocks NAC's long-term anti-relapse effects but not the immediate reduction in drug-seeking.
- NAC combined with extinction training shows promise for long-term addiction treatment.