Romboutsia ilealis related metabolite OAA controls obesity and lipid metabolism through PSMD3-mediated degradation of YTHDF2 - PubMed
3 hours ago
- #lipid metabolism
- #obesity
- #gut microbiota
- Romboutsia ilealis is identified as a gut bacterium that alleviates obesity and metabolic disorders by suppressing intestinal lipid absorption.
- The metabolite 2-oxoindole-3-acetate (OAA) mediates the effect of R. ilealis by interacting with the 26S proteasome subunit PSMD3.
- OAA-PSMD3 interaction destabilizes YTHDF2, leading to derepression of Rxrb mRNA and increased expression of CD36 and FABP2, promoting lipid absorption.
- The study highlights R. ilealis and OAA as potential next-generation probiotic or metabolite-based therapies for obesity.