Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection - PubMed
3 hours ago
- #HSV-1
- #disease-tolerance
- #neuroimmunology
- Sensory neurons produce substance P (SP) and TAFA4 during viral infection to promote disease tolerance.
- SP from TRPV1+ sensory neurons limits neutrophil infiltration in the skin via MRGPRA1, aiding healing.
- TAFA4 in dorsal root ganglia (DRGs) works with IL-10 to resolve inflammation post-viral clearance.
- These neuroimmune pathways enhance host fitness without directly affecting pathogen elimination.
- The study highlights the role of the sensory nervous system in disease tolerance mechanisms.