Risk score for early mortality to stratify for intensive SSc therapy in the EUSTAR network: the RESIST score - PubMed
3 hours ago
- #Risk Stratification
- #Mortality Prediction
- #Systemic Sclerosis
- The RESIST score was developed to predict early mortality (<5 years) in systemic sclerosis (SSc) patients eligible for intensive therapies.
- Key factors in the RESIST score include male sex, diffuse cutaneous SSc, age >55 years, elevated C-reactive protein, digital ulcers, modified Rodnan skin score >14, left ventricular ejection fraction <60%, and diffusing capacity of the lung for carbon monoxide <60%.
- Patients were stratified into low (99% 5-year survival), intermediate (96%), and high-risk (82%) groups based on the RESIST score.
- The model demonstrated good discrimination with AUCs of 0.79 in the development cohort and 0.78 in the validation cohort.
- The RESIST score aims to guide treatment decisions by identifying high-risk SSc patients who may benefit from intensive therapies.