Duzhong-Gegen formula ameliorated hyperuricemia by enhancing renal uric acid excretion through activation of SIRT1 - PubMed
7 hours ago
- #Renal excretion
- #Hyperuricemia
- #SIRT1 activation
- Duzhong-Gegen formula (DGF) reduces serum uric acid, BUN, serum creatinine, renal injury, and inflammation in hyperuricemic mice.
- DGF increases urine volume, urinary uric acid excretion, and expression of UA transporters ABCG2 and OAT1 in the kidneys.
- Cafestol, a bioactive component in DGF, activates SIRT1, leading to upregulation of the NRF2/ABCG2/OAT1 pathway for UA excretion.
- Knockdown of SIRT1 blocks the beneficial effects of cafestol, confirming its role in mediating DGF's anti-hyperuricemic action.