Nature-inspired confined cascade enzyme nanoreactors for targeted atherosclerosis therapy - PubMed
2 days ago
- #nanoreactor
- #antioxidant
- #atherosclerosis
- Nature-inspired nanoreactor (USPB@SeDMSN@NM) developed for targeted atherosclerosis therapy.
- Nanoreactor mimics superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities.
- Ultrasmall Prussian blue nanoparticles (USPB NPs) assembled into selenium-doped dendritic mesoporous silica nanoparticles (SeDMSNs).
- Neutrophil membrane coating enables targeted delivery to atherosclerotic plaques.
- Efficiently mitigates inflammation and reduces lipid accumulation in macrophages.
- Shows significant antiaging effects by protecting DNA from oxidative damage.
- Offers a novel approach for high-efficiency plaque microenvironment modulation.