Polymorphisms in GPCR genes: Their role in schizophrenia, autism diseases and response to antipsychotic treatment - A systematic review - PubMed

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Polymorphisms in GPCR genes are associated with schizophrenia (SZ) and autism spectrum disorder (ASD).
301 GPCR polymorphisms were identified as risk variants for SZ and/or ASD.
171 polymorphisms were linked to SZ, mainly in DRD2 and DRD3 genes.
55 polymorphisms were associated with ASD, primarily in OXTR and AVPR1A genes.
GPCR variants influence antipsychotic treatment response.
In SZ, DRD2 mutations affect clozapine and risperidone response, while HTR2A mutations influence olanzapine response.
In ASD, HTR2C mutations impact risperidone response.
Functional consequences were described for 59 polymorphisms, with DRD2 being the most studied.
The review highlights the genetic overlap and neurodevelopmental origins of SZ and ASD.

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