Divergent inflammatory and neurology-related protein levels in long COVID following primary and breakthrough SARS-CoV-2 infections - PubMed
3 hours ago
- #immune response
- #inflammatory proteins
- #long COVID
- Long COVID involves persistent symptoms over 3 months post-SARS-CoV-2 infection, affecting 5-30% of individuals.
- Study measured 182 inflammatory and neurology-related plasma proteins using multiplexed affinity proteomics in cohorts including long COVID patients, recovered individuals, and healthy controls.
- Key discriminating proteins between long COVID and other groups included IL-20, HAGH, NAAA, CLEC10A, LXN, MCP-1, TRAIL, G-CSF, NBL1, and CCL23.
- Longitudinal analysis showed differing plasma protein levels after primary infection versus after booster vaccination or breakthrough infection.
- Findings suggest an altered immune response upon re-exposure (e.g., vaccination or reinfection) in individuals with long COVID compared to the initial infection.